OBJECTIVE： To investigate the effect and cost of Multidimensional iron oral liquid and Polysaccharide iron complex capsules in the treatment of iron deficiency anemia during pregnancy. METHODS： By retrospective study， 80 cases of iron deficiency anemia during pregnancy were divided into control group and trial group in accordance to different therapy plans， with 40 cases in each group. Control group was given Multidimensional iron oral liquid orally， 10 ml each time， bid， after breakfast and supper， for consecutive 4 weeks； trial group was given Polysaccharide iron complex capsules orally， 0.30 g each time， qd， for consecutive 4 weeks. Clinical efficacy， erythrocyte related lab indexes， satisfactory rate and ADR were compared between 2 groups， and cost-effectiveness analysis was adopted for economic evaluation. RESULTS： The total effective rate of experimental group was 95.0％， which was higher than 85.0％ of control group， but without statistical significance （P＞0.05）； hemoglobin level， erythrocyte count and average volume of erythrocyte of trial group were significantly higher or more than control group， and satisfactory rate （95.0％ vs. 65.0％） were significantly higher than control group， with statistical significance （P＜0.05）； no obvious ADR was found in 2 groups. Total cost of trial group and control group were 243.60 and 166.32 yuan， and cost-effective ratio was 2.56 and 1.96； incremental cost-effective ratio was 7.73. Results of sensitivity analysis were same to the result. CONCLUSIONS： Both Multidimensional iron oral liquid and Polysaccharide iron complex capsules can improve anemia in patients with iron deficiency anemia during pregnancy. Polysaccharide iron complex capsules show better therapeutic efficacy and satisfactory rate， but it is relatively expensive. Drugs should be selected according to economic situation.