OBJECTIVE： To provide reference for promoting the further implementation of national essential medicine system and rational use of drugs in community health service center. METHODS： Outpatients’ information in Changqiao Street Community Health Service Center from Sept. 2， 2009 to Nov. 25， 2014 was collected to statistically analyze the drug variety， the number of prescriptions， the consumption sum and the DDDs before and after the implementation of essential medicine system and after the supplement of non essential medicines. RESULTS： Essential medicines occupied the main position of drug utilization in each stage， with substantial growth in respects of consumption sum and number of prescriptions； the sum of Chinese patent drugs and essential cardiovascular drugs occupied more than 50％ of the total consumption sum and number of prescriptions， with higher growth rate； essential medicines occupied the top 10 in respects of consumption sum and DDDs， among which most were the drug varieties in “Shanghai supplement essential drugs in community health service center” （2010 Edition）， with some overlap the varieties in “National Essential Medicine System” （2012 Edition）； cardio-cerebrovascular drugs occupied the dominant position； the growth rates of cefotiam and atorvastatin took up the top 2 ranking in the list of consumption sum， while the growth rates of calcium carbonate D3 and irbesartan and hydrochlorothiazide took up the top 2 ranking in the list of DDDs. CONCLUSIONS： Essential medicine catalog covers the common drugs in the community health service center， in which the rational use of Chinese patent drugs and antibacterial deserves needs to be noticed. The clinical rational use of the essential medicines should be strengthened， the essential medicine catalog should be adjusted and non essential medicines should be supplied when necessary in order to truly meet the needs of patients and optimize the allocation of medical resources.