OBJECTIVE： To explore the similarity of dissolution profiles of self-development and original preparation of Solifenacin succinate tablet， and provide reference for the prescription and process screening of the former one and the quality similarity evaluation of the latter one. METHODS： The paddle method was adopted with rotational speed of 50 r/min， using water， pH1.2 hydrochloric acid solution， pH4.0 acetate buffer solution and pH6.8 phosphate buffer solution as dissolution media， HPLC was used to determine the cumulative dissolution of main components of self-development and original preparation of Solifenacin succinate tablet at different time points， dissolution profile was drew， then f2 was used to evaluate its similarity. RESULTS： In the 4 dissolution media， the f2 of both self-development and original preparation of Solifenacin succinate tablet was higher than 50， which indicated that the dissolution profiles showed similarity. CONCLUSIONS： The established HPLC is suitable for the dissolution determination of Solifenacin succinate tablet； the dissolution profiles of the self-development and original preparations are basically similar， which indicates the prescription and technology of self-development preparation are feasible.