OBJECTIVE： To observe the clinical efficacy and safety of parecoxib preventing hyperalgesia after remifentanil hydrochloride anesthesia. METHODS： 140 patients undergoing selective laparoscopic cholecystectomy were selected from our hospital and randomly divided into group A， B， C and D， with 35 cases in each group. Drug use of 4 groups before anesthesia induction was in line with anesthesia induction plan. Anesthesia maintenance plan was that continuous pump of Remifentanil hydrochloride for injection [0.1 μg/（kg·min） for group A and C， 0.3 μg/（kg·min） for group B and D]+Propofol injection 4-8 mg/（kg·h）+Cisatracurium besilate for injection 0.12 mg/（kg·h）； group C and D were given parecoxib 40 mg， iv， 15 min before the end of surgery. HR， MAP， the amount of remifentanil hydrochloride and propofol， awareness recovery time， extubation time， alertness/sedation score （OAA/S） immediately after extubation， VAS score were observed， and the occurrence of ADR was recorded. RESULTS： HR and MAP of 4 groups immediately after extubation were increased， compared to after entering surgery room， especially in group B， with statistical significance （P＜0.05）. The amount of remifentanil hydrochloride in group B and D were significantly higher than in group A and C， and OAA/S of group C and D immediately after extubation were significantly higher than those of group A and B， with statistical significance （P＜0.05）. VAS score of group B， C and D were significantly lower than those of group A 1， 2， 6， 12， 24 h after surgery， the group D was significantly lower than the group C， with statistical significance （P＜0.05）. The case number of supplemental analgesic drugs and ADR as dysphoria， shiver in group B， C and D were significantly lower than in group A. The radio of supplemental analgesic drugs and dysphoria in group D were significantly lower than in group C， with statistical significance （P＜0.05）. CONCLUSIONS： Parecoxib 40 mg 15 min before the end of surgery can effectively prevent the occurrence of hyperalgesia after remifentanil hydrochloride anesthesia with good safety.