OBJECTIVE： To establish a method for simultaneous residual determination of dichloromethane and ethyl acetate in bisacodyl raw material. METHODS： Head-space GC was performed on the capillary column of 6％ cyanopropyl phenyl-94％ dimethyl polysiloxane （DB-624） by temperature programming， the temperature of injector was 220 ℃， detector was flame ionization detector with temperature of 250 ℃， carrier gas was high purity nitrogen with the flow rate of 3.0 ml/min， split ration was 1 ∶ 10， headspace heating temperature was 70 ℃， equilibration time was 30 min， volume of  headspace vial was 5 ml， and the injection volume was 1 ml. RESULTS： The linear range was 6-120 μg/ml for dichloromethane （r＝0.999 9） and 50-1 000 μg/ml for ethyl acetate （r＝0.999 9）； the limit of quantitation was 0.2， 1.7 μg， limit of detection was 0.06， 0.5 μg； RSDs of precision， stability and reproducibility tests were no higher than 3％； recoveries were 100.30％-102.00％ （RSD＝0.63％，n＝9） and 100.10 ％-101.30％ （RSD＝0.44％，n＝9）. CONCLUSIONS： The method is simple and accurate， and can be used for the simultaneous residual determination of dichloromethane and ethyl acetate in bisacodyl raw material.