OBJECTIVE： To provide reference for improving the effect of clinical pharmacy undergraduate interns（hereinafter referred to interns）. METHODS： Representative cases were selected from the reference books， teaching design， summary of past interns and database retrieve， problem-based learning （PBL） was used for teaching； teaching evaluation was performed by the triple evaluation in the end of class. RESULTS & CONCLUSIONS： The interns generally accepted the teaching method and got qualified results. Selecting cases from many ways， cases combined with PBL circumvent the shortages of traditional case method， such as narrow channels of case source， single content， low learning interest of students and poor sense of participation； the new method mobilizes the subjective initiative of interns， accelerates the cultivation of interns’ clinical thinking ability； it also helps to promote the shift of “passive teaching” to “active teaching” and improves the teaching awareness and levels of teachers.