OBJECTIVE： To investigate the effects of uterine arterial embolization combined with Methotrexate and Lactate ethacridine on related indexes of mid-pregnant patients with placenta previa abortion. METHODS：The data of 100 mid-pregnant patients with placenta previa who required inducing labor was retrospectively analyzed and divided into observation group （50 cases） and control group （50 cases） by different treatment. Control group received uterine arterial embolization before inducing labor， then received Lactate ethacridine injection 100 mg， amniotic injection + Mifepristone tablet 75 mg， and aborted after 2 d. Observation group received uterine arterial embolization after uterine arterial perfusionon both sides， then received Methotrexate for injection 50 mg/side after uterine arterial embolization catheter entering uterine artery， Lactate ethacridine injection （the same usage and dosage as control group）+Mifepristone tablet （the same usage and dosage as control group） was given after 12 h. Total parturition， intrapartum hemorrhage， hospitalization time， menstruation recovery time， cesarean section， hysterectomy， retained placenta and clearing palace in 2 groups were observed， and postoperative complications were recorded. RESULTS： Intrapartum hemorrhage， hospitalization time， cesarean section rate and hysterectomy rate in observation group were significantly lower than control group， with statistical significance （P＜0.05）， while there were no significant differences in total parturition， menstruation recovery time， retained placenta rate and clearing palace rate in 2 groups （P＞0.05）. There was no significant difference in the incidence of postoperative complications in 2 groups （P＞0.05）. CONCLUSIONS： Uterine arterial embolization combined with Methotrexate and Lactate ethacridine can effectively reduce the hemorrhage of mid-pregnant patients with placenta previa abortion， shorten hospitalization time， and decrease cesarean section and hysterectomy rate.