OBJECTIVE： To provide reference for rational use of antidepressive drugs. METHODS： In retrospective study， the utilization of antidepressive drugs in 31 hospitals of Nanjing area during 2013-2015 was analyzed statistically in respects of consumption sum， DDDs， DDC， B/A， etc. RESULTS： There were a total of 20 kinds of antidepressive drugs in 31 hospitals of Nanjing area， and total consumption sum increased year by year， increasing from 76 085 200 yuan in 2013 to 100 812 500 yuan in 2015， increased by 17.43％ compared to 2014 and by 12.83％ compared to 2015. The top 4 drugs in the list of consumption sum and DDDs were paroxetine， escitalopram， sertraline and venlafaxine. The sum of their consumption sum accounted for more than 60％ of total consumption sum. The consumption sum of plant antidepressive drugs increased rapidly. B/A and DDC of antidepressive drugs kept stable each year compared to last year， among which DDC of doxepin， clomipramine and amitriptyline was less than 2 yuan， B/A values of sertraline， fluvoxamine， flupentixol and melitracen， doxepin， clomipramine and amitriptyline were all more than 1.00. CONCLUSIONS： Of antidepressive drugs in 31 hospitals of Nanjing area during 2013-2015， selective serotonin reuptake inhibitors and selective serotonin-norepinephrine reuptake inhibitors took up dominant place， and plant antidepressive drugs is promising in the future．