OBJECTIVE： To analyze the dyeing status of cinnabar and its pieces， and provide reference for its quality clinical safetey appicaton. METHODS： TLC was used for the qualitative identification of amaranth， carmine， erythrosine， acid red 73， 808 udan and indirubin. HPLC-MS was used to detect the 808 udan ： HPLC conditions were as follows， column was Acquity UPLC BEH C18 with mobile phase of cetonitrile-0.1％ formic acid （70 ∶ 30，V/V） at a flow rate of 0.3 ml/min， the detection wavelength was 520 nm； MS conditions were as follows， ion source was electrospray ionization source， scanning mode was positive ion scanning with full scanning tandem mass spectrometry， nebulizer pressure was 30 psi， drying gas was nitrogen， ion spray voltage was 4 000 V， collision energy was 30 V， and the injection volume was 5 μl. The volumetric method was used for content determination of HgS. RESULTS： TLC spots of amaranth， carmine， erythrosine， acid red 73， 808 udan and indirubin were clear and well-separated. 4 batches of 808 udan dyeing were included in the 18 batches of samples， 6 batches had non-compliance contents （including 3 batches of 808 udan dyeing）. CONCLUSIONS： Dyeing-doped and other quality problems exist in the cinnabaris in markets， which should be noticed.