OBJECTIVE： To investigate the general regularity and characteristics of ADR induced by quinolones， and to provide reference for rational drug use in the clinic. METHODS： A total of 84 quinolones-induced ADR reports in our hospital from 2011 to 2014 were analyzed statistically in respects of general information， drug use， organs/systems involved in ADR， clinical manifestations， outcome and DDDs. RESULTS： The adverse reactions were caused by 7 kinds of drugs， among which 89.29％ of them were caused by intravenous injections， manifesting as lesion of skin and its appendants， digestive system and nervous system injury， etc. The proportion of female patients （60.71％） was higher than that of male （39.29％）. No serious ADR was found， and all patients were recovered or cured. CONCLUSIONS： Gatifloxacin injection shows the low safety. The monitoring of ADR induced by quinolones should be strengthened to ensure the safe and effective use of drugs.