OBJECTIVE： To explore the effect of propofol target-controlled infusion on extubation time in patients with ENT surgery under Narcotrend classification guidance. METHODS： 52 patients with endotracheal intubation intravenous anesthesia and minimally invasive ENT surgery received target-controlled infusion for anesthesia induction and anesthesia. NI value， plasma concentration of propofol （cm）， mean arterial pressure （MAP）， pulse oxygen saturation （SpO2） before anesthesia and different time points in recovery period， the correlation of NI with propofol cm of all patients were recorded，and NI with propofol cm and time when extubation was omalysed. RESULTS： There were no significant differences in SpO2 before anesthesia and different time points in recovery period （P＞0.05）； MAP was significantly higher than before anesthesia at T3， MAP was significantly lower than before anesthesia at T0-T1， propofol cm was T0＞T1＞T2＞T3＞T4＞T5， NI was significantly lower than before anesthesia at T0-T3， and T0＜T1＜T2＜T3， the differences were statistically significant （P＜0.05）， and there were no significant differences between T4-T5 and before anesthesia （P＞0.05）. NI when extubation was（86.17±5.29）， propofol cm was （0.96±0.31） μg/ml， and average extubation time was （8.26±2.93） min. When extubation， NI showed negative correlation with propofol cm（r＝－0.812）； and decreased with the prolong of extubation time （r＝－0.792）； the predictive rates of NI and propofol cm's prediction awareness change in recovery period were 0.93 and 0.86. There were no obvious adverse reactions during treatment. CONCLUSIONS： Propofol target-controlled infusion under Narcotrend classification guidance can accurately predict the awareness change from no response to stimuli to shouting and opening eyes， has a high reference value on extubation time.