OBJECTIVE： To provide reference for rational use of second class of psychotropic drugs in the clinic. METHODS： The second class of psychotropic drugs in outpatient department of our hospital during 2012-2015 were analyzed retrospectively in respects of the number of common drugs prescription， distribution of gender/age/disease diagnosis， DDDs and DUI， etc. RESULTS： During 2012-2015， second class of psychotropic drugs in outpatient department of our hospital accounted for 25.09％ of total prescription amout. The drugs with high use frequency were alprazolam， clonazepam， lorazepam and estazolam， accounting for 93.10％ of total prescription amount of second class of psychotropic drugs. The proportion of male to female was 1 ∶ 1.50； the patients aged 19-35 years old took up the biggest proportion， accounting for 34.62％. The proportion of schizophrenia prescription was the highest， accounting for 45.17％. DDDs of alprazolam was the highest， being 742 141.67； its DUI was 1.075； DUI of other drugs was lower than 1.0. CONCLUSIONS： The use of second class of psychotropic drugs is basically reasonable in our hospital. Guiding principles of Clinical Application of Psychotropic Drugs should be implemented strictly and continously to avoid abuse of second class of psychotropic drugs.