OBJECTIVE： To study the protective effects of Li medicine Chushi qufeng decoction on arthritis model rats. METHODS： 60 rats were randomly divided into normal group， model group， positive group and Chushi qufeng decoction high-dose， medium-dose and low-dose groups [45.9， 22.95， 11.48 g（crude drug）/kg]. Except for normal group， those groups were given chicken type Ⅱ collagen to induce arthritis model. After modeling， normal group and model group were given normal saline intragastrically， once a day， for consecutive 12 d； Chushi qufeng decoction groups were given relevant medicine intragastrically； positive group was given leflunomide 4.5 mg/kg on 1st-3rd day and 1.8 mg/kg on 4th-12th day. The degree of joint lesion in rats were scored. The degree of joint swelling was determined as well as the serum levels of TNF-α， IL-1β and type Ⅱ collagen antibody. RESULTS： Compared with normal group， arthritis index， degree of joint swelling， the serum levels of TNF-α， IL-1β and type Ⅱ collagen antibody increased significantly in model group （P＜0.01）. Compared with model group， pathological score of positive group and Chushi qufeng decoction high-dose group decreased significantly， and serum levels of TNF-α， IL-1β and type Ⅱ collagen antibody decreased significantly in treatment groups （P＜0.05 or P＜0.01）. CONCLUSIONS： Li medicine Chushi qufeng decoction has certain protective effect on arthritis model rats induced by chicken type Ⅱ collagen.