OBJECTIVE： To provide reference for rational use of antithyroid drugs （ATD） in the clinic. METHODS： Retrospective analyzed 60 cases of adverse reaction caused by Methimazole and Propylthiouracil in terms of age，gender， incubation period，organ or system involved and clinical manifestation， which were searched from 2004 May-2014 Dec. in First Affiliated Hospital of Soochow University. RESULTS： Among 60 ADR cases， male was more than female， and the ratio of male to female was 1 ∶ 2.75； average age was（39.7±13.4）years old， and 83.3％ ADR occurred between 20 and 59 years old； 66.7％ ADR occurred within 30 days. Most common clinical manifestations were drug-induced liver disease （66.7％， 40/60） and neutropenia （25％， 15/60）. There was statistical significance in the proportion of drug-induced liver disease caused by methimazole and propylthiouracil in all ADR cases （P＜0.05）， there was no statistical significance in the proportion of agranulemia caused by these two drugs （P＞0.05）. CONCLUSIONS： Before and after the treatment of antithyroid drugs， it’s necessary to check hepatic function and the number of neutrophile granulocyte， and we should monitor and follow up it to ensure the safe use of drugs.