OBJECTIVE： To investigate the role of clinical pharmacists in the treatment for patients with chronic renal failure. METHODS： Clinical pharmacists participated in the treatment process for a patient with chronic renal failure during uremia period； assisted physicians to optimize and improve therapy plan from correcting anemia， controlling blood pressure， improving heart function and regulating ion disorder， etc.； suggested adding dosing frequence of Felodipine sustained-release tablet， Metoprolol tartrate tablet and Shenqiong glucose injection， and giving Benazepril hydrochloride tablet and Isosorbide 5-mononitrate sustained-release tablet. They also suggested adjusting the dosage of rhEPO and the dosage form of ferralia， increasing the dosage of Calcitriol capsule and Calcium carbonate tablet， decreasing dosing frequence of 5％ Glucose injection and Levocarnitine for injection， and giving Vitamine B12 tablet. Therapeutic efficacy and ADR should be observed closely during treatment， and medication education should be performed for the patient. RESULTS： Physicians adopted the suggestions of clinical pharmacists. The patient was improved and discharged from hospital with drugs 28 days later. CONCLUSIONS： Clinical pharmacists participate in the individualized treatment for patients with chronic renal failure and assist physicians to optimize therapy plan， which promote the clinical effectiveness and safety of drug treatment.