OBJECTIVE： To study the effect of long-term follow-up of Valsartan and amlodipine tablets （Ⅰ） on blood pressure control and renal protection of patients with refractory hypertension. METHODS： 120 patients with refractory hypertension were divided into control group and observation group according to the patients’ wishes， with 60 cases in each group. All patients accepted the triple therapy of amlodipine+valsartan+hydrochlorothiazide and life-style intervention； at the time of discharge from hospital， the blood pressure was well controlled. After discharge from hospital， control group was given amlodipine； observation group was given Valsartan and amlodipine tablet （Ⅰ） orally， 1 tablet each time， qd， and dose increasing according to blood pressure， with maximal dose no more than 2 tablets. With 18 months of follow-up， blood pressure and renal function indexes of 2 groups were observed at different time points， and blood pressure control rate and the rate of renal function injury were also observed at the last follow-up； the occurrence of ADR was observed. RESULTS： 2 cases and 3 cases were follow-up loss in observation group and control group， respectively. With 12 and 18 months of follow-up， 24 h systolic pressure， 24 h diastolic pressure and 24 h urine protein of 2 groups increased significantly while creatinine clearance rate decreased significantly compared with before discharge； but the indexes of observation group was better than that of control group， with statistical significance （P＜0.05）. At last follow-up， the rate of blood pressure in observation group was significantly higher than in control group （84.5％ vs. 52.6％）， the rate of renal function injury was significantly lower than control group （8.6％ vs. 24.6％）， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Valsartan amlodipine tablet （Ⅰ） has obvious advantages in long-term follow-up of blood pressure control of patients with refractory hypertension. It can significantly reduce the incidence of renal function injury with good safety.