OBJECTIVE： To provide reference for improving the rational drug use of China. METHODS： By referring to India， South Africa and Argentina's policy in this regard， the rational drug policy rules and supporting measures in the national drug policy of these states were analyzed and summarized to put forward related policies for China. RESULTS & CONCLUSIONS： Promoting the rational drug use required multi-angle managements towards the supply-side， the demand-side as well as third-party， and relevant supporting measures needed to be improved. Firstly， the managements on the supply-side is particularly important， including measures such as strengthening prescription management， formulating and implementing the standard treatment guidelines， intensifing the functions of pharmacists， establishing serious irrational drug use and specific diseases medication management system； then， the demand-side needs the investigation and feedback about the patients with drug use to eliminate irrational drug use， and through the internet and other media to raise public awareness of the medicine information as well； besides， the third-party needs to establish a non-profit organization to regulate pharmaceutical advertisements， and increase information about rational drug use； finally， improving the rational drug policy also needs to improve needs to promote the separation of medicine， reform Medicare payment and other supporting measures.