OBJECTIVE： To establish a method for the simultaneous determination of ornidazole and dexamethasone sodium phosphate in Compound ornidazole film. METHODS： HPLC was performed on the column of Inertsil ODS-3 with mobile phase of methanol-20 mmol/L phosphate buffer （pH was adjusted to 7.40 with glacial acetic acid）（55 ∶ 45，V/V） at a flow rate of 1.0 ml/min， column temperature was 30 ℃， detection wavelength was 242 nm and volume injection was 10 μl. RESULTS： The linear range were 1-100 μg/ml for both ornidazole （r＝0.999 7） and dexamethasone sodium phosphate （r＝0.999 9）； RSDs of precision， stability and reproducibility tests were lower than 2.0％； recoveries were 96.50％-99.80％ （RSD＝1.02％，n＝9） and 96.50％-99.60％（RSD＝0.99％，n＝9）. CONCLUSIONS： The method is specific with good precision and stability and high accuracy， and can be used for the simultaneous determination of ornidazole and dexamethasone sodium phosphate in Compound ornidazole film.