OBJECTIVE： To establish a method for the rapid contents determination of potassium chloride and calcium chloride in Compound sodium chloride injection. METHODS： After diluted in appropriate way， Compound sodium chloride injection was sampled directly and contents of potassium chloride and calcium chloride were determined simultaneously by ICP-OES. The powder was 1 300 W， plasma gas flow rate was 15 L/min， auxiliary cooling gas flow was 0.2 L/min， atomizer flow rate was 0.8 L/min， the peristaltic pump rate was 0.8 L/min， atomizer pressure was 315 kPa， and the observation was axial observation， analysis spectral lines of potassium and calcium were 766.490 nm and 315.887 nm. RESULTS： The linear ranges of potassium and calcium were 1.0-12.0 mg/L （r＝0.999 7 and 0.999 9）； RSDs of precision and reproducibility tests were lower than 1％； recoveries were  98.5％-100.5％ （RSD＝0.59％，n＝9） and 99.3％-102.3％ （RSD＝0.98％，n＝9）. CONCLUSIONS： The method is simple， rapid and simple， and can be used for the quality control of Compound sodium chloride injection.