OBJECTIVE： To optimize water extraction technology of Shenqi yiqi capsules. METHODS： The water extraction technology of Shenqi yiqi capsules was optimized by L9（34）orthogonal test with amount of water added， decoction times and decoction time as factors using the extraction rate of astragaloside， calyosin-7-O-β-D-glycoside， icariin and bergenin as index， and the verification test was made. RESULTS： The best extraction technology was as follows as 8-fold water， decocting for 3 times， 2 h each time； comprehensive score of 3 batches of samples in validation test were 98.95， 99.71 and 99.98 （RSD＜2％， n＝3）. CONCLUSIONS： The water extraction technology optimized by multi-index comprehensive score-orthogonal test is stable， scientific and reasonable.