OBJECTIVE： To introduce the experience on how to build modern pharmaceutical logistics and dispensing system in outpatient pharmacy， and to provide reference for the construction of modern outpatient pharmacy. METHODS： The pharmaceutical logistics system could be constructed by setting up secondary warehouse， pharmaceutical supply chain management system （PSCMS） and electronic drug storage system （EDSS）； pharmaceutical dispensing system could be constructed through allocating automatic drug dispensing machine with different functions reasonably to carry out dispensing way of different modes combination， building automated pharmacy management system and developing emergency plan for the system fault of the automated pharmacy. The effects of logistics and dispensing system in our hospital were evaluated through comparing related index before and after the application of the systems. RESULTS： With the aid of PSCMS， the drug purchase information could be collected and calculated automatically， the frequency and working time of the purchase were reduced by 50％ and 75％ respectively， and the accuracy of the purchase plan was increased by 12.5％； with the EDSS， the position and number information of the drugs could be acquired immediately， and the complementation and inventory time were decreased by 67％ and 58％ respectively； the time for manual dispensing was reduced by 68％， and the incidence of internal mistakes was decreased by 76.7％； under new dispensing system， the prescription could be distributed automatically and intelligently， the rate of automatic prescription processing was increased to 72.7％， and the average waiting time to pick up drugs was controlled to below 10 min. CONCLUSIONS： The pharmacists’ working efficiency and the quality of pharmaceutical care have been improved by the modern pharmaceutical logistics and dispensing system， which settle the foundation for the transformation of the pharmaceutical care mode.