OBJECTIVE： To investigate the consumption of drugs after the inplementation of total cost prospective payment system （PPS）， and to provide reference for hospital drug cost control. METHODS： The data of prescriptions collected from 9 hospital during 2007-2014 were divided into group A， B and C according to PPS， and then summarized statistically in respects of increase rate of total consumption sum， consumption sum ratio of major category； the drug cost per time of outpatient department， emergency department and inpatient department were calculated as well as consumption sum ratio of self-paid drugs； the dosage per time of drugs in blood pressure and diabetes prescription were also calculated. RESULTS： The total consumption sum of drug increased slowly after the implementation of total cost PPS； the consumption sum ratio of major category kept stable， while that of anti-infective agent decreased； the emergency drug cost per time achieved a negative growth， and outpatient and inpatient drug cost per time increased slightly. The proportion of self-paid drugs was relatively stable. The dosage per time of drugs in hypertension and diabetes prescriptions was stable， too. CONCLUSIONS： Total cost PPS is useful in controlling the rapid growth of drug costs， and promote the reasonable drug use. The consumption sum of self-paid drugs are well controlled. The increase of drug cost per time in outpatient and inpatient should arouse the attention of the relevant departments. In addition， it has no effect on drug dosage for the patients with hypertension and diabetes.