OBJECTIVE： To explore the effects of Xinnaoxin pills on CAT score， cardiopulmonary function and hemorheology of patients with pulmonary heart disease complicating with coronary heart disease. METHODS： In retrospective study， 80 cases of pulmonary heart disease complicating with coronary heart disease were randomly divided into control group and observation group with 40 cases in each group. Control group was given routine treatment as relieving asthma， eliminating phlegm and oxygen inhalation， anti-infective treatment， correcting acid-base balance， cardiotonic and diuretic treatment. Observation group was additionally given Xinnaoxin pills 1.0 g/time， bid after meal， on the basis of control group. CAT score， cardiopulmonary function and hemorheology index were compared between 2 groups before and after treatment as well as ischemic ECG improvement effect and the occurrence of ADR after treatment. RESULTS： After treatment， hematocrit hematocrit had changed slightly among hemorheology indexes， and CAT score， other hemorheology indexes and cardiopulmonary function indexes were improved significantly； the improvement of observation group was better than that of control group， with statistical significance （P＜0.05）. Total effective rate of ischemic ECG was 90.0％ in control group and 92.5％ in observation group， there was no statistical significance （P＞0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Xinnaoxin pills can effectively improve CAT score and cardiopulmonary function of patients with pulmonary heart disease complicating with coronary heart disease. It also can improve hemorheology and shows good clinical efficacy， but great importance should be attached to the safety of drug use in the clinic.