OBJECTIVE： To optimize the extraction technology of Baiyi rectal solution. METHODS： The effects of water amount and extraction time on extraction technology were investigated by central composite design-response surface method using OD value of berberine hydrochloride and ferulic acid and the extract yield as index. Validation test was also conducted. RESULTS： The optimal extraction technology was as 11-fold water， decocting 70 min for the first time； 5-fold water， decocting 30 min for the second time. In validation test， OD value of first extraction was 0.940 0， and the bias between observed and predicted values was －2.07％； that of second extraction was 0.851 8， and the bias was －2.41％. CONCLUSIONS： The extraction technology of Baiyi rectal solution is reasonable， feasible and suitable for industrial production.