OBJECTIVE： To optimize the preparation technology of Sinomenine topical paste. METHODS： Using “initial viscous force”， “holding viscous force” and “peeling strength” as index， heating and stirring time （A， h）， heating temperature （B， ℃） and the sequence of adding composition （softening agent， blank matrix and sinomenine） （C） as influential factors， the preparation technology of Sinomenine topical paste was optimized by orthogonal test and verified. At the same time， the content of sinomenine was determined by HPLC method.  RESULTS： The optimal preparation technology of Sinomenine topical pasta was as follows as adding blank matrix and sinomenine， and then adding softening agent， heating at 80 ℃， stirring for 1 h. In verification test， RSD of comprehensive score for 3 batches of samples were 2.09％ （n＝3）； average contents of samples were 6.7 mg/g， which was in line with the requirement of ≥6.0 mg/g. CONCLUSIONS： The optimal preparation technology of Sinomenine topical pasta is reasonable， stable and feasible. The paste shows good adhesiveness and is qualified in content.