OBJECTIVE： To construct surgery base drug management system， and to realize efficient and accurate drug management in surgery room. METHODS： The functions of surgery base drug management system exploited by our hospital were introduced， and the effect of the system was evaluated in department of anesthesiology. RESULTS & CONCLUSIONS： The system possesses the functions of surgery drug automated affiliated charge， standardized narcotics prescription autogeneration， discarded narcotics prescription auto-prescribing， and drug information summary statisticing and checking， etc. After the application of the system， nonstandard rate of prescription decreased from 12.7％ of handwritten prescription to 0.1％ of electronic prescription； the time of drug requisition and checking decreased from （8.5±1.6） min to 0 min and （7.6±1.0） min to （2.9±0.9） min （P＜0.05 or P＜0.01）. The system standardizes medication behavior of physicians and improve their work efficiency， avoid the loophole of drug charge management， realize the consistency between the accounts and the real numbers of narcotics， improve the rate of quality prescriptions and narcotics management，  and realize integration， automation， intellectualization and whole-course supervision of drug management in pharmacy and clinical departments.