OBJECTIVE： To improve the quality of pharmacist consultation， provide real-time， precise and whole-process medicine guidance and to promote rational drug use. METHODS： The functions of electronic pharmacy consultation system （EPCS） in our hospital were introduced， and its effects were evaluated. RESULTS： The system had several modules as multiple dimensional knowledge assistant system， real-time prescription checking engine， electronic consultation record method， pharmacist workload and quality statistical analysis. EPCS provided convenient information access， prescription auditing， consultation record and statistical analysis so as to improve consultation efficiency and accuracy. Compared with before using EPCS， EPCS had enhanced speed of inquiring information by 3.75 times， prescription auditing by 4 times， consultation record by 6 times and statistical analysis by 20 times； return visit rate to potients increased from 0.03％ to 0.34％. The number of consulting questions increased month by month. The type of consultation question， the identity of the consultant and others could be classified statistically based on the system. CONCLUSIONS： EPCS helps pharmacist to build a more scientific and effective consultation platform， and promotes rational drug use in the hospital.