OBJECTIVE： To investigate the effects of Wenxin granule on the related indexes of senile patients with primary hypertension and acute left cardiac failure. METHODS：160 senile patients with primary hypertension and acute left cardiac failure were randomly divided into control group （80 cases） and observation group （80 cases）. Control group received 12.5 mg captopril， orally， twice to 3 times a day （if patients had taken plenty of diuretic drugs， in low sodium and/or low blood volume， patients with normal or low blood pressure， the initial dose was 6.25 mg， 3 times a day）. Observation group additionally given 9 g of Wenxin granule， 3 times a day. The treatment course for both groups was 4 weeks. SBP，DBP， PP， SDANN，SDNN-Index， RMSSD， PNN50， improvement of cardiac functions before and after treatment， and incidence of adverse reactions in 2 groups were observed. RESULTS： After treatment， the SBP， DBP and PP in 2 groups were significantly lower than before， and observation group was lower than control group， SDNN， SDANN， SDNN-Index、RMSSD and PNN 50 were significantly higher than before， and observation group was higher than control group， the differences were statistically significant （P＜0.05）. And there was no significant difference in the incidence of adverse reactions（P＞0.05）. CONCLUSIONS： Based on conventional treatment，wenxin granule can significantly reduce the bloop pressure of senile patients with primary hypertension and acute left cardiac failure， improve cardiac functions and inhibit autonomic disorders， with good safety.