ABSTRACT    OBJECTIVE： To investigate the clinical characteristics and regularity of adverse drug reaction （ADR）， and to provide reference for rational and safe drug use in the clinic. METHODS： ADR reports collected from our hospital by Guangdong ADR Monitoring Center during Jan. 2014 to June. 2015 were summarized and analyzed statistically. RESULTS： Of 433 ADR cases， there were 185 male cases （42.73％） and 248 female cases （57.27％）， with ratio of 1 ∶ 1.34. The incidence of ADR was in high level （71.59％） in young and middle-aged patients （20-59 year-old）； that of male was significantly lower than that of female （1 ∶ 1.37）. ADR cases caused by intravenous drip （48.04％） and oral administration （41.57％） were most common. The most ADR cases were related with anti-infective drugs （167 cases， 38.57％）， mainly were related with cephalosporins （64.07％）. Organs/systems involved in ADR were main the damages of gastrointestinal system （262 cases， 36.19％） and the lesion of skin and appendants （237 cases， 32.73％）. The serious ADR was mainly induced by anti-infective and anti-tumor drugs. CONCLUSIONS： Clinical medical personnel should strengthen the ADR monitoring of cephalosporin antibiotics and anti-tumor drug， and select route of administration carefully.