OBJECTIVE： To observe the clinical efficacy and safety of Biyuan tongqiao granule combined with Triamcinolone acetonide spray in the treatment of chronic rhinosinusitis. METHODS： 120 patients with chronic rhinosinusitis were randomly divided into observation group and control group， with 60 cases in each group. Control group was given Triamcinolone acetonide spray 220 μg， qd， in first week， decreasing to 110 μg， qd； observation group was additionally given Biyuan tongqiao granule 15 g， tid， on the basis of control group. Both groups were treated continuously for 10 weeks. The clinical efficacy of 2 groups were observed as well as the levels of MTR， IL-5 and IL-8， SNOT-20 score， VAS score and Lund-Mackey sinus CT score before and after treatment. The incidence of ADR was compared between 2 groups. RESULTS： Total effective rate of observation group was 93.3％， which was significantly higher 85.0％ of control group， with statistical significance （P＜0.05）. There was no statistical significance in IL-5， IL-8， MTR， SNOT-20 score， VAS score and Lund-Mackey sinus CT score between 2 groups before treatment （P＞0.05）. IL-5 and IL-8 levels of 2 groups decreased significantly， while MTR， SNOT-20 score， VAS score and Lund-Mackey sinus CT score were decreased significantly； the observation group was better than the control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Biyuan tongqiao granule combined with Triamcinolone acetonide spray is effective in the treatment of chronic rhinosinusitis， and can effectively improve the quality of life and relieve clinical symptom with good safety.