OBJECTIVE： To optimize the technology of supercritical CO2 extraction from Zingiberis rhizoma. METHODS： With the comprehensive score of the contents of 6-ginger phenol， 8-ginger phenol and 10-ginger phenol and the extraction rate of the oil from Z. rhizoma as the index， uniform design method was adopted to investigate the effects of extraction pressure， extraction temperature and extraction duration on the extraction result； verification tests were conducted. RESULTS： The optimal conditions were as follows as the extraction pressure of 25 MPa， extraction temperature of 30 ℃ and extraction duration of 2 h. In the verification tests， the average extraction rate of the oil from Z. rhizoma was 3.2％ （n＝3）， and the comprehensive score was 1.874 2 （RSD＝0.65％， n＝3）， with the relative deviation of 0.6％ between the measured value and the predicted value. CONCLUSIONS： The optimal extraction technology is stable and feasible， with the advantages of low temperature， short duration.