OBJECTIVE： To provide reference for the innovation of chronic disease management mode by combing internet big data with foreign and domestic chronic disease management experience. METHODS： Innovative strategies for chronic disease management in internet big data era were explored from respective of pharmacists， based on national condition， referring to international chronic disease management. RESULTS： The development of internet big data era brought thinking of pharmacists about new type chronic disease management mode. Pharmacists established chronic disease patients medication safety management center based on big data platform， and provided full-range and multi-level pharmaceutical care， including real-time intervention， personalized pharmaceutical care， human concern and timeless and spaceless patient education， clinical evidence-based medicine. CONCLUSIONS： Big data-based chronic disease management mode could reduce the risk of drug use， promote rational drug use， and open a new era of “patient-centered” pharmaceutical care conception and pharmacist’s function transformation.