OBJECTIVE： To investigate the role of clinical pharmacists in the therapy for sever acute pancreatitis induced by hyperlipidemia （HL-SAP） patient. METHODS： Clinical pharmacists participated in the therapy for a pregnant patient with HL-SAP after cesarean section， assisted physicians to optimize therapy plan through analyzing the disease condition according clinical guide and relevant literatures. Clinical pharmacists suggested to decrease atorvastatin 20 mg， qd to 10 mg， qd in order to avoid the risk of rhabdomyolysis and liver injury. When patient’s hemogram kept stable and infection had been controlled， clinical pharmacists suggested antibiotics de-escalation treatment： Levofloxacin injection 0.5 g， ivgtt， qd+Metronidazole injection 0.5 g， ivgtt， q12 h instead of meropenem. RESULTS： Physicians adopted the suggestions of clinical pharmacists. The patient was recovered and transfer to gastroenterology department 15 d later. CONCLUSIONS： Clinical pharmacists provide pharmaceutical care for HL-SAP patient after cesarean section， and assist physicians to formulate therapy plan so as to reduce the incidence of ADR effectively and guarantee the safe and effective use of drugs.