OBJECTIVE： To Provide reference for improving teaching levels of New Drug Clinical Research and training for pharmaceutical research talents. METHODS： The experiment teaching in 2013 graduate student of the Fourth Military Medical University was taken as a pilot， different teaching methods were introduced in various chapters of New Drug Clinical Research， and appraisal system was perfected. RESULTS & CONCLUSIONS： Some appropriate methods are established， for example， conductive teaching， problem-based learning， spot-teaching and bilingual-teaching. The appraisal system including usual performance and research proposal is established， it has improved enthusiasm and initiative of students， promoted teaching quality， obtained certain achievements， which provides reference for the training methods on the cultivation of innovative and professional pharmaceutical talents.