OBJECTIVE： To analyze and compare the congruity between Maria and DDW-J standard and Roussel uclaf causality assessment method（RUCAM） for diagnosing drug-induced liver injury （DILI）， and evaluate its application. METHODS： In retrospective analysis， the clinical data of 122 patients with DILI with RUCAM ≥3 scores was quantitatively scored by Maria and DDW-J standard， χ2 test was conducted for statistical analysis. RESULTS： Among the 122 cases， 120 cases （98.4％） were classified as “likely and possible” by DDW-J standard， which was significantly higher than the 58 cases （47.5％） that classified as “possible” by Maria standard， with statistical significance； and compared with Maria standard， DDW-J standard was more closer to RUCAM scoring results. CONCLUSIONS： DDW-J standard is superior to Maria standard， and close to RUCAM scoring results for DILI； RUCAM is still the DILI diagnostic evaluation system with high accuracy and operability.