OBJECTIVE： To investigate the clinical efficacy of levodopa combined with comprehensive therapy for ametropic amblyopia children and teenagers and its effeets on pattern visual evoked potential （P-VEP） and visual function. METHODS： 70 patients （80 eyes） with ametropic amblyopia were randomly divided into observation group （35 cases， 40 eyes）and control group （35 cases， 38 eyes）. Control group received comprehensive therapy as wearing correctional glasses， occlusion therapy and visual stimulation training； observation group additionally received levodopa 0.125 （d1-3）-0.25 g/time， bid， on the basis of control group for 6 months. Therapeutic efficacy， P-VEP， Visual sensitivity and visual function were compared between two groups， and the occurrence of ADR was recorded. RESULTS： The effective rate of observation group （92.50％） was significantly higher than that of control group （76.32％）， with statistical significance （P＜0.05）； the wave amplitude of P-VEP P100 in observation group were significantly greater than in control group， and the incubation period was significantly shorter than control group， with statistical significance （P＜0.05）； visual acuity under different spatial frequency contrast were significantly higher than control group， and correction convergence range and correction separation range of observation group were significantly greater than those of control group， while corrected near stereo vision was significantly less than control group， with statistical significance （P＜0.05）. There was no statistical significance in ADR incidence between 2 groups （P＞0.05）. CONCLUSIONS： Levodopa combined with comprehensive therapy can improve the function of visual central neurons， and improve visual acuity and binocular stereo vision functions so as to improve therapy efficacy.