OBJECTIVE： To optimize the ethanol mixed-extraction technology of Red ginseng and Salvia miltiorrhiza in Xinlikang granules. METHODS： L9（34） orthogonal test was adopted to optimize ethanol mixed-extraction technology with ethanol volume fraction， amount of ethanol and extraction times as factors using weighting coefficient comprehensive score of the contents of ginsenoside Rg1， Re and Rb1 in R. ginseng and the contents of tanshinone ⅡA and salvianolic acid B in S. miltiorrhiza as index； and the verification test was detected. RESULTS： Optimal mixed-ethanol extraction technology was as follows as 6-fold 70％ ethanol， reflux extracting for 3 times， 2 h each time. In verification test， average contents of ginsenosides Rg1， Re， Rb1 in R. ginseng and those of tanshinone ⅡA and salvianolic acid B in S. miltiorrhiza were 3.963 8， 0.757 3， 4.986 2， 0.964 7， 27.662 5 mg/g， respectively， and comprehensive score was 0.96 （RSD＝1.26％， n＝3）. CONCLUSIONS： Ethanol extraction technology of R. ginseng and S. miltiorrhiza in Xinlikang granules optimized by multiple indexes comprehensive score combined with orthogonal test is stable， reasonable and feasible.