OBJECTIVE： To investigate the effects of Astragalus injection combined with Salmeterol propionate powder inhalation on pulmonary function， cytokines and blood rheology indexes of Chronic obsrnctine pulmonary disease （COPD） patients. METHODS： 104 COPD patients were divided into observation group and control group according to the randorn number table method， with 52 cases in each group. Control group was given routine symptomatic treatment+Salmeterol propionate powder inhalation 1 dose， bid； observation group was additionally given Astragalus injection 30 ml added into 5％ Glucose injection 250 ml， ivgtt， qd， on the basis of control group. Treatment course of 2 groups lasted for 2 weeks. Clinical efficacy， pulmonary function indexes [forced expiratory volume in one second （FEV1）， forced vital capacity （FVC）， FEV1/FVC]， CRP， cytokine [IL-6， IL-8， TNF-α] levels， blood rheology indexes （whole blood high-shear viscosity， whole blood low-shear viscosity， fibrinogen， hematokrit and plasma viscosity）， and the occurrence of ADR were observed in 2 groups. RESULTS： The total effective rate of observation group （94.23％） was significantly higher than that of control group （75.00％）； compared with before treatment， FEV1， FVC and FEV1/FVC of 2 groups were significantly increased after treatment， and those of observation group were significantly higher than those of control group； CRP， IL-6， IL-8 and TNF-α of 2 groups were significantly decreased， and those of observation group were significantly lower than those of control group. The whole blood high-shear viscosity， whole blood low-shear viscosity， fibrinogen， hematocrit and plasma viscosity of observation group were decreased significantly after treatment， and the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. No significant ADR was found in 2 groups. CONCLUSIONS： Astragalus injection combined with Salmeterol propionate powder inhalation is significantly effective for COPD， improves pulmonary function of patients， improves micro inflammatory state and decreases blood rheology indexes with good safety.