OBJECTIVE： To investigate the effect and safety of Shengmai injection on myocardial function of patients with general anesthesia of hysterectomy. METHODS： 40 patients underwent hysterectomy were randomly divided into observation group and control group with 20 cases in each group. Both groups received general anesthesia induction of fentanyl citrate and rocuronium， and inhalation anesthesia of propofol. Observation group was given Shengmai injection 1 ml/kg，ivgtt；control group was given same dose of 0.9％ Sodium chloride injection， ivgtt， before anesthesia. Mean arterial pressure （MAP）， heart rate （HR）， central venous pressure （CVP）， blood oxygen saturation （SpO2）， the levels of MDA， SOD and NOS were compared between 2 groups before operation （T0）， before anesthesia induction （T1）， reaction during （T2）， after operation（T3）. The occurrence of ADR was also observed. RESULTS： There was no statistical significance in MAP and HR between 2 groups at T0 and T1 （P＞0.05）. ?MAP and HR of observation group was significantly higher than those of control group at T2 and T3， with statistical significance （P＜0.05）.There was no statistical significance in CVP and SpO2 between 2 groups at different time points （P＞0.05）. There was no statistical significance in MDA， SOD and NOS levels between 2 groups at T0 （P＞0.05）. MDA and NOS levels of 2 groups increased significantly at T1， T2 and T3， while SOD level decreased significantly； MDA and NOS level of observation group were lower than the control group while SOD level was higher than control group at T1， T2， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Shengmai injection can maintain stable HR and MAP， and reduce the oxide in patients underwent hysterectomy surgery so as to protect myocardial function with good safety.