OBJECTIVE： To provide reference for investigating the disease burden of diabetic patients and promoting rational drug use. METHODS： Open-ended questionnaires were adopted to survey the willingness to pay （WTP） of some diabetic patients in Sichuan Provincial People’s Hospital and collect the data about personal information， health status， the affordability of disease and WTP， the data was sorted with Excel （version 2013） software by two operators and analyzed with SPSS 17.0 software by step-wise multiple linear regression to explore the influential factors of WTP values. RESULTS： Totally 120 questionnaires were sent out and 106 were effectively received with effective rate of 88.3％. The average age of respondents was （59.9±13.9） years old， the average body mass index （BMI） of respondents was （24.5±0.5） kg/m2， the highest proportion of monthly diabetes fees was no more than 300 yuan， followed by more than 300-500 yuan and more than 500-1 000 yuan； the awareness rates of fasting plasma glucose （FPG）， 2 h postprandial blood glucose （2 h PG） and glycated hemoglobin （HbA1c） were 95.3％， 86.8％ and 68.9％， respectively； and patients with more than 2 complications accounted for 29.5％. The WTP values of respondents to the complete recovery of HbA1c， FPG and 2 h PG were 1 604.1， 1 617.9 and 1 683.7 yuan/month， the median values were 1 000 yuan/month； the WTP values of respondents to the 10％ recovery were 867.4， 908.5 and 877.9 yuan/month， the median values were 500， 575 and 510 yuan/month， respectively. The influential factors with positive effects and significant differences on WTP values in step-wise multiple linear regression were total annual household income， complications， hospital experience， family history of diabetes， diabetes mental status and cost of diabetes in the past months； those with negative effects and significant differences on WTP values were age， FPG level and education level. CONCLUSIONS： Diabetic patients， particularly， with peripheral neuropathy， high blood lipids or diabetic foot have higher WTP value， which shows they hole heavier mental burden and disease burden than others. Patients recovered 10％ percent were closer to actual treatment state， which better show the influential factors of WTP values actually， and patients with a family history of diabetes， depressed mood， higher fees in the average monthly cost， and hospital patients have higher WTP values.