OBJECTIVE： To investigate the role of compatibility on clinical efficacy action of the prescription containing Curcuma zedoaria， and to improve the pertinence of drug use by medical staff and clinical efficacy of C. zedoaria. METHODS： By reviewing relevant literatures， the prescriptions containing C. zedoaria were selected to summarize the effects of compatibility on clinical efficacy of C. zedoaria. RESULTS： 345 prescriptions containing C. zedoaria were collected， mainly including the compatibility of C. zedoaria with traditional Chinese medicine which promote the circulation of qi， activate blood and remove blood stasis， tonify deficiency， warm interior and clear heat. The prescriptions containing C. zedoaria with sparganii often included Rhizoma Sparganii and C. zedoaria， involving 219 prescriptions （13.94％）. CONCLUSIONS： C. zedoaria have the effects of activating blood stagnation， promoting the circulation of qi， removing food retention and relieving pain； different compatibility greatly influence the clinical efficacy of C. zedoaria； common couplet medicines are R. Sparganii and C. zedoaria， and it can play the role of activating blood stagnation， promoting the circulation of qi， removing food retention and relieving pain； Common Vladimiria Root combined with Rheum palmatum can promote the circulation of qi and relieve pain. Medical staff should prescribe the prescriptions and use drugs for the compatibility of C. zedoaria based on clinical demands.