OBJECTIVE：To observe the effects of hemofiltration combined with Jisheng shenqi pill on protein and energy reserves of uremia patients. METHODS：124 uremia patients were randomly divided into control group（n＝60） and test group （n＝64）. Control group was given 250-300 ml/min hemofiltration， 4 h for every times， 3 times a week； test group was additionally given 9 g Jisheng shenqi pill， twice a day. The treatment course for both groups was 12 months. Hemoglobin （Hb）， blood urea nitrogen （BUN）， glutamate aminotransferase （ALT）， albumin （ALB）， serum transferrin （TF）， plasma fibronectin （FN）， systolic blood pressure， diastolic blood pressure， mean arterial pressure； body mass index （BMI）， subcutaneous fat thickness and arm muscle circumference in 2 groups before and after treatment were observed. RESULTS： After treatment， Hb， TF and FN levels in 2 groups were significantly higher than before， test group was higher than control group； ALT， ALB， BUN levels， systolic blood pressure， diastolic blood pressure and mean arterial pressure were significantly lower than before， test group was lower than control group； there were significant differences in the BMI， subcutaneous fat thickness and arm muscle circumference between control group and before and test group（P＜0.05），but there was no significant difference in the BMI， subcutaneous fat thickness and arm muscle circumference in test group before and after treatment（P＞0.05）. CONCLUSIONS： Hemofiltration combined with Jisheng shenqi pill can improve microenvironment in vivo and immune function， reduce accelerated metabolic induced by inflammation and improve protein and energy reserves to improve life quality of patients.