OBJECTIVE： To provide reference for rational use of antidepressant drugs in the clinic. METHODS： By DDD analysis recommended by WHO， the utilization of antidepressant drugs in 34 hospital from Nanjing area during 2011-2014 were analyzed statistically in respects of main type， consumption sum， DDDs and DDC， etc. RESULTS： The consumption sum and DDDs of antidepressants were increased year by year in 34 hospital from Nanjing area during 2011-2014， with the average annual growth rate of 18.21％ and 19.25％ respectively. The top 2 drugs by DDDs were paroxetine and setraline； DDC of tomoxetine， trazodone and dutoxetine took up the first 3 place； consumption sum of paroxetine， setraline， venlafaxine and escitalopram took up the first 4 places； consumption sum of paroxetine， mirtazapine and citalopram synchronized with their DDDs， and serial number ratio was close to or equal to 1.00. CONCLUSIONS： The use of antidepressant drugs in 34 hospitals from Nanjing area is rational in structure and level； selective 5-hydroxytryptamine （5-HT） reuptake inhibitors （SSRI） and selective 5-HT noradrenaline reuptake inhibitor （SNRI） take up the predominant place； new type of antidepressant drugs are used widely and of great use potentiality in the future.