OBJECTIVE： To observe the clinical efficacy and safety of Fuzi xiaoyao powder combined with rapid acupuncture in the treatment of depression. METHODS： A total of 80 depression patients were randomly divided into observation group and control group， with 40 cases in each group. Control group was treated with paroxetine 20 mg， qd； observation group was given Fuzi xiaoyao powder 200 ml， one dose a day， at third， combined with rapid acupuncture. Two groups of patients for 6 days for a course of treatment， a total of 6 courses of treatment. Clinical efficacy， HAMD， serum content of 5-HT and Asberg side reaction scale （SERS） were observed in 2 groups. RESULTS： The effective rate of observation group was 82.5％， which was significantly higher than 62.5％ of control group， with statistical significance （P＜0.05）； after treatment， HAMD of 2 groups decreased significantly， and the observation group was lower than the control group， with statistical significance （P＜0.05）. Compared with before treatment， erum content of 5-HT increased significantly in 2 groups after treatment， with statistical significance （P＜0.05）； there was no statistical significance between 2 groups （P＞0.05）. After treatment， SERS of observation group was significantly lower than that of control group， with statistical significance （P＜0.05）. CONCLUSIONS： Fuzhi xiaoyao powder combined with rapid acupuncture show certain therapeutic efficacy in the treatment of depression，with good safety