OBJECTIVE： To observe clinical efficacy of extracorporeal shock wave lithotripsy combined with Paishi decoction in the treatment of kidney stone. METHODS： 160 patients with kidney stone were selected and randomly divided into observation group and control group， with 80 cases in each group. Control group only received HB-ESWL-VG extracorporeal shock wave lithotripsy； observation group additionally received Paishi decoction 300 ml， tid， for consecutive 1 week， on the basis of control group. Clinical efficacy was observed in 2 groups； the levels of serum inflammatory factor IL-2， IL-6， TNF-α， T lymphocyte subset CD3+， CD4+， CD8+ and CD4+/CD8+， erythrocyte immune function indicator C3b receptor rosette （C3bRR）， immunity complex rosette （ICR） and tumor erythrocyte rosette （TER） level were detected in 2 groups before and after treatment. RESULTS： The effective rate of observation group （98.75％） was significantly higher than that of control group （91.25％）， with statistical significance （P＜0.05）. After treatment， the levels of IL-2， IL-6 and TNF-α in observation group was significantly lower than in control group， the levels of CD3+， CD4+， CD4+/CD8+， C3bRR， ICR and TER were significantly higher than control group， with statistical significance （P＜0.05）. Comparsion of CD8+ between 2 groups was not statistically significant（P＞0.05）. CONCLUSIONS： The extracorporeal shock wave lithotripsy combined with Paishi decoction can relieve inflammation reaction， enhance immune function and improve therapeutic efficacy.