OBJECTIVE： To study the purification technology of 4 active components from Tripterygium wilfordii by macroporous resin. METHODS： The purification abilities of nine macroporous resins（ADS-5， ADS-8， HPD100， HPD300， HPD400， HPD450， HPD700， HPD722 and HPD750） were studied with the adsorption and desorption rates of triptolide， wilforlide， triptonide and tripterine as the index by static adsorption and desorption experiments for 4 active components from T. wilfordii， so as to screen optimal macroporous resins. Using transfer rate of active component as index， single factor test was used to investigate the effects of different sampling method， ratio of mixing sample to total resin quantity， ratio of resin to medicinal material， cleaning solution （type， amount and cleaning flow rate）， diameter- height ratio of resins， eluant （volume， flow rate） on adsorption， so as to determine the optimal elution technology； validation test was also conducted. RESULTS： HPD722 macroporous resin was chosen as adsorption resin； ratio of diameter to height was 1 ∶ 10， resin-medicinal material ratio was 1 ∶ 2， and ratio of mixing sample to total resin quantity was 1 ∶ 10； wet column installing and mixing resin for sample loading were adopted. The macroporous resin was washed with 12 BV 20％ ethanol at the rate of 12 BV/h， and then eluted with 12 BV 95％ ethanol at the rate of 6 BV/h. The verification test results showed that the total transfer rate of 4 active components from T. wilfordii was more than 90％ （RSD＝0.99％， n＝3）.  CONCLUSIONS： The optimized technology is stable and feasible， and suitable for the purification of 4 active components from T. wilfordii.