OBJECTIVE： To optimize the extraction technology of Qingjie atomized liquid. METHODS： The extraction technology of Qingjie atomized liquid was optimized by orthogonal test with hyperoside content as index， using the amount of added water， extraction time and extraction times as factors， and the verification test was conducted. RESULTS： The optimal extraction technology was as follows as 12-folds water， extracting for 2 times and 1 hour each time. The content of hyperoside was 4.129 μg/g in 3 validation tests （RSD＝1.81％， n＝3）. CONCLUSIONS： The optimal extraction technology is stable and practical， and can provide reference for the formulation of technology and quality standard for Qingjie atomized liquid.