OBJECTIVE： To prepare andrographolide phospholipid compound， optimize its formulation technology and characterizeit. METHODS： Andrographolide phospholipid compound was prepared with solvent method. Using compound rate as index， the effects of reaction solvent， reaction time， reaction temperature， drug concentration， the ratio of reactants and other single factors on compound rate were investigated. The ratio of reactants， reaction temperature and drug concentration were optimized by orthogonal test and validated. The dissolubilities of andrographolide， andrographolide phospholipid physical mixture and andrographolide phospholipid compound in water， soybean oil and Lauroglycol FCC were compared and characterized with UV and DSC. RESULTS： The optimal preparation technology was tetrahydrofuran as reaction solvent， reaction time of 4 h， reaction temperature of 50 ℃， drug concentration of 10 mg/ml， ratio of andrographolide to phospholipid 1 ∶ 3. The compound rate of andrographolide phospholipid compound was 83.2％ （n＝3）. Compared with raw material and physical mixture， phospholipid compound significantly improved the dissolubility of andrographolide in water， soybean oil and Lauroglycol FCC. UV and DSC showed that compound had been prepared. CONCLUSIONS： Andrographolide phospholipid compound is prepared successfully.