OBJECTIVE： To observe the efficacy and safety of salbutamol sulfate by atomized inhalation in the treatment of pediatric asthmatic disease. METHODS： 156 children with asthmatic disease were randomly divided into control group （78 cases） and observation group （78 cases）. Control group was given oxygen inhalation， anti-infection， relieving cough and reducing phlegm， aminophylline and other conventional treatment； observation group was additionally given 0.03 ml/kg salbutamol sulfate， adding into 2 ml 0.9％ Sodium chloride injection， putting into mask atomizer for nebulization， 5-10 min every time， twice a day. They were treated for 5 d. Clinical efficacy， asthma remission time， pulmonary rales disappearing time， average hospitalization days and incidence of adverse reactions in 2 groups were observed. RESULTS： The total effective rate in observation group was significantly higher than control group， asthma remission time， pulmonary rales disappearing time and average hospitalization days were significantly shorter than control group， the differences were statistically significant （P＜0.05）. There were obvious adverse reactions in 2 groups during treatment. CONCLUSIONS： Based on conventional treatment， salbutamol sulfate by atomized inhalation has obvious efficacy in the treatment of pediatric asthmatic disease， with good safety.