OBJECTIVE： To evaluate the quality of anticoagulant therapy in patients who took warfarin and provide data supporting for strengthening the management of these patients. METHODS： A retrospective analysis of related clinical data of 214 patients who meet the inclusion criteria was performed. RESULTS： The average time for patients took warfarin was （321.64±189.50） d， average times for tested INR was （12.01±7.03） times in clinic； when anticoagulant therapy， INR＜2.0 accounted for 51.96％， 2.0≤INR≤3.0 accounted for 39.13％， and INR>3.0 accounted for 8.91％； patients with target INR≤2.0 accounted for 45.33％， target INR＝2.5 accounted for 38.32％， and target INR≥3.0 accounted for 0.93％； the average TTR was （50.80±22.32）％； and there was no statistical significance in the TTR of different ages and diseases （P＞0.05）. CONCLUSIONS： The anticoagulant therapy in some patients who took warfarin shows poor quality， it needs strengthening the quality management to make it safe and effective.